Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels
نویسندگان
چکیده
Mol. Nutr. Food Res. 2023, 67, 202200293 DOI: 10.1002/mnfr.202200293 Pyrrolizidine alkaloid N-oxide (PANO), a common plant-based food protoxin, can be reduced to pyrrolizidine (PA) by liver S9 and gut microbiota, causing toxicity carcinogenicity. In article number 2200293, Frances Widjaja co-workers used new approach methodologies predict the relative potency (REP) of PANO PA in both rats humans at low high dose levels.
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ژورنال
عنوان ژورنال: Molecular Nutrition & Food Research
سال: 2023
ISSN: ['1613-4125', '1613-4133']
DOI: https://doi.org/10.1002/mnfr.202370009